A rhodamine based near-infrared fluorescent probe for selective detection of Cu2+ ions and its applications in bioimaging

被引：2

作者：

Chang, Zhijian ^{[1
]}

Li, Shumeng ^{[2
]}

Ye, Jia-Hai ^{[1
]}

Lin, Fuyan ^{[1
]}

Chen, Yuncong ^{[2
]}

Guo, Zijian ^{[2
]}

Gong, Xuedong ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem & Chem Engn, Nanjing 210094, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

来源：

ANALYTICAL METHODS | 2024年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

RECOGNITION; SENSOR; CHEMODOSIMETER; CHEMOSENSOR; DERIVATIVES;

D O I：

10.1039/d4ay01922a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel near-infrared fluorescent probe TM2 based on a rhodamine-bearing framework was disclosed with a large Stokes shift (100 nm). TM2 exhibits highly selective recognition for Cu2+ in EtOH/H2O (1 : 1, v/v) solution with a low detection limit (2.3 mu M) and a wide detection range (0-50 mu M). Detection of Cu2+ is undisturbed at physiological pH levels of 5-9. This recognition mechanism is attributed to the formation of a 1 : 1 complex between TM2 and Cu2+, validated by Job's plot, 1H NMR titration, and LC-MS experiments. Moreover, the successful fluorescence imaging of Cu2+ both in vitro and in vivo was also accomplished.

引用

页码：178 / 183

页数：6

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