Hydrogels Based on Polyelectrolyte Complexes: Underlying Principles and Biomedical Applications

被引：3

作者：

Sim, Belynn ^{[1
,2
]}

Chang, Jun Jie ^{[1
]}

Lin, Qianyu ^{[1
]}

Wong, Joey Hui Min ^{[1
]}

Ow, Valerie ^{[1
,3
]}

Leow, Yihao ^{[1
,2
]}

Wong, Yi Jing ^{[1
,2
]}

Boo, Yi Jian ^{[1
]}

Goh, Rubayn ^{[1
]}

Loh, Xian Jun ^{[1
,2
,4
]}

机构：

[1] ASTAR, Inst Mat Res & Engn IMRE, Singapore 138634, Singapore

[2] Nanyang Technol Univ NTU, Sch Mat Sci & Engn, Singapore 639798, Singapore

[3] Natl Univ Singapore NUS, Dept Biomed Engn, Singapore 117583, Singapore

[4] Natl Univ Singapore NUS, Dept Mat Sci & Engn, Singapore 117576, Singapore

来源：

BIOMACROMOLECULES | 2024年 / 25卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

OPPOSITELY CHARGED POLYELECTROLYTES; POLYION-COMPLEX; INJECTABLE GEL; NITRIC-OXIDE; IN-VITRO; DELIVERY; ALGINATE; TOUGH; STIFFNESS; DESIGN;

D O I：

10.1021/acs.biomac.4c01240

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ionic complexes of electrostatically charged biomacromolecules are key players in various biological processes like nucleotide transportation, organelle formation, and protein folding. These complexes, abundant in biological systems, contribute to the function, responsiveness, and mechanical properties of organisms. Coherent with these natural phenomena, hydrogels formed through the complexation of oppositely charged polymers exhibit unique attributes, such as rapid self-assembly, hierarchical microstructures, tunable properties, and protective encapsulation. Consequently, polyelectrolyte complex (PEC) hydrogels have garnered considerable interest, emerging as an up-and-coming platform for various biomedical applications. This review outlines the underlying principles governing PEC hydrogels. The classification of polyelectrolytes and the self-assembly of PEC hydrogels are discussed, including the factors influencing their self-assembly process. Recent developments of PEC hydrogels for biomedical applications, including drug delivery, tissue engineering, wound healing and management, and wearable sensors, are summarized. This review concludes with the prospective directions for the next generation of PEC hydrogel research.

引用

页码：7563 / 7580

页数：18

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