Construction and drug release performance of thermosensitive copolymer-modified hollow mesoporous silica and the composite nanofibers

被引：0

作者：

Pei, Wenxiang ^{[1
]}

Ma, Shijie ^{[1
]}

Yang, Langfei ^{[1
]}

Gao, Yujie ^{[1
]}

Wu, Jindan ^{[1
]}

机构：

[1] College of Textile Science and Engineering, International Institute of Silk, Zhejiang Sci-Tech University, Hangzhou,310018, China

来源：

Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica | 2024年 / 41卷 / 10期

关键词：

Anesthetics - Atom transfer radical polymerization - Atomic emission spectroscopy - Controlled drug delivery - Electron spin resonance spectroscopy - Electrospinning - Fibrous membranes - Fourier transform infrared spectroscopy - Grafting (chemical) - Mesoporous materials - Mineral wool - Nanofibers - Near infrared spectroscopy - Silica nanoparticles - Silicones - Targeted drug delivery;

D O I：

10.13801/j.cnki.fhclxb.20240203.003

中图分类号：

学科分类号：

摘要：

Traditional drug-loaded nanofibers face challenges such as unstable drug loading and excessively rapid release. In light of these issues, this study employs a thermosensitive copolymer (P(NIPAM-co-AM)) to coat hollow mesoporous silica nanoparticles (HMSN), incorporating them as drug carriers in conjunction with poly(Ε-caprolactone) (PCL) nanofibers. The drug release and antibacterial performance of the composite nanofiber membrane were investigated. Firstly, the HMSN surface was functionalized through free radical polymerization by grafting a copolymer of isopropylacrylamide (NIPAM) and acrylamide (AM) (P(NIPAM-co-AM)). Hydrophobic drug ciprofloxacin (CIP) was loaded into the modified nanoparticles (P(NIPAM-co-AM)-HMSN or PHMSN). The analysis of the microstructure, composition, and temperature-responsibility of the drug-loaded particles were performed using SEM, TEM, TG, BET analysis, FTIR, UV-Vis spectroscopy, etc. Blending PCL with drug-loaded PHMSN, a composite fibrous membrane (CIP@PHMSN-PCL) was fabricated using electrospinning. CIP@PHMSN-PCL exhibited temperature-stimulated drug releasing, with cumulative release rates of CIP reaching 90.78% and 72.67% at 45℃ and 25℃ after 72 h, respectively. The Korsmeyer-Peppas model apply described the drug release kinetics, suggesting the diffusion as the primary mechanisms for drug release from the composite fiber membrane. At 45℃, the drug-loaded fiber membrane exhibited a 100% inhibition rate against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). At 25℃, the inhibition rates were 92.34% and 95.83% against E. coli and S. aureus, respectively, demonstrating temperature-dependent drug release performance of the CIP@PHMSN-PCL membrane. In summary, the drug-loaded PHMSN composite nanofiber membrane exhibits temperature-regulated drug release functionality and excellent antibacterial activity, holding potential application value in the biomedical field. © 2024 Beijing University of Aeronautics and Astronautics (BUAA). All rights reserved.

引用

页码：5400 / 5411