Csp3-Csp2 Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process

被引：3

作者：

Martin, Maria ^{[1
,2
]}

Romero, Rafael Martin ^{[1
,2
]}

Portolani, Chiara ^{[1
,2
,3
]}

Tortosa, Mariola ^{[1
,2
,4
]}

机构：

[1] Univ Autonoma Madrid UAM, Organ Chem Dept, Madrid 28049, Spain

[2] Univ Autonoma Madrid UAM, Ctr Innovat Adv Chem ORFEO CINQA, Madrid 28049, Spain

[3] Alma Mater Studiorum Univ Bologna, Dept Ind Chem Toso Montanari, I-40129 Bologna, Italy

[4] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain

来源：

ACS CATALYSIS | 2024年 / 14卷 / 23期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

Deamination; Isonitriles; Photoredox Catalysis; C-N Cleavage; Pyridines; C-H BONDS; DIRECT ARYLATION; CROSS-COUPLINGS; ACTIVATION; ISOCYANIDE; CONVERSION; ALCOHOLS; STRATEGY; ACIDS;

D O I：

10.1021/acscatal.4c06269

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp3-Csp2 bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules.

引用

页码：17286 / 17292

页数：7

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