Synthesis of oxa-bridged carbocycles via rhodium/Lewis acid catalyzed [3 + 3] and [4 + 3] cycloadditions of carbonyl ylides with donor–acceptor strained carbocycles

被引：1
|
作者：
Li, Jiale [1 ]
Wang, Lingfei [1 ]
Liu, Pei-Nian [1 ,2 ]
Li, Xingguang [1 ]
机构：
[1] Shanghai Key Laboratory of Functional Materials Chemistry, Key Laboratory for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai,200237, China
[2] State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing,210009, China
来源：
Organic Chemistry Frontiers | / 12卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Catalysis; -; Cycloaddition;
D O I：
10.1039/d4qo01831a
中图分类号：
学科分类号：
摘要：
A method for cooperative rhodium/Lewis acid-catalyzed [3 + 3] and [4 + 3] cycloadditions of carbonyl ylides with donor–acceptor (D–A) strained carbocycles is described. It affords access to a wide range of structurally diverse oxa-bridged carbocycles with high efficiency and stereoselectivity. This method operates under mild conditions, exhibits good step and atom economy, and can be extended to [3 + 2] cycloadditions with D–A 1,2-dipoles, enabling the construction of oxa-bridged spirocycles. © the Partner Organisations 2025.
引用
收藏
页码：491 / 496
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