Hydrogel-Based Strategies for Liver Tissue Engineering

被引：1
作者：
Zhang, Yu [1 ,2 ]
Li, Luofei [1 ]
Dong, Liang [1 ]
Cheng, Yuanqi [1 ]
Huang, Xiaoyu [1 ]
Xue, Bin [1 ]
Jiang, Chunping [2 ]
Cao, Yi [1 ,2 ]
Yang, Jiapeng [1 ,2 ]
机构：
[1] National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, Nanjing
[2] Jinan Microecological Biomedicine Shandong Laboratory, Jinan
来源：
Chem and Bio Engineering | 2024年 / 1卷 / 11期
基金：
中国国家自然科学基金;
关键词：
3D bioprinting; acute liver failure; cell culture; hepatotoxicity testing; hydrogel; liver regeneration; liver tissue engineering; liver-on-a-chip; organoid;
D O I：
10.1021/cbe.4c00079
中图分类号：
学科分类号：
摘要：
The liver’s role in metabolism, detoxification, and immune regulation underscores the urgency of addressing liver diseases, which claim millions of lives annually. Due to donor shortages in liver transplantation, liver tissue engineering (LTE) offers a promising alternative. Hydrogels, with their biocompatibility and ability to mimic the liver’s extracellular matrix (ECM), support cell survival and function in LTE. This review analyzes recent advances in hydrogel-based strategies for LTE, including decellularized liver tissue hydrogels, natural polymer-based hydrogels, and synthetic polymer-based hydrogels. These materials are ideal for in vitro cell culture and obtaining functional hepatocytes. Hydrogels’ tunable properties facilitate creating artificial liver models, such as organoids, 3D bioprinting, and liver-on-a-chip technologies. These developments demonstrate hydrogels’ versatility in advancing LTE’s applications, including hepatotoxicity testing, liver tissue regeneration, and treating acute liver failure. This review highlights the transformative potential of hydrogels in LTE and their implications for future research and clinical practice. © 2024 The Authors. Co-published by Zhejiang University and American Chemical Society.
引用
收藏
页码：887 / 915
页数：28
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