Rhodium(<sc>iii</sc>)-catalyzed direct C-H activation of 2-aryl-3H-indoles: a strategy for 4-heteroaryl pyrazole synthesis

被引：0

作者：

Yang, Zi ^{[1
]}

Luo, Ji ^{[2
]}

Zhang, Wenbo ^{[2
]}

Lei, Jieni ^{[1
]}

Liu, Chaoshui ^{[2
]}

Li, Yaqian ^{[1
]}

机构：

[1] Changsha Med Univ, Hunan Prov Univ Key Lab Fundamental & Clin Res Fun, Changsha 410219, Peoples R China

[2] Changsha Med Univ, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, Changsha 410219, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 02期

关键词：

RH(III)-CATALYZED SYNTHESIS; DIAZO-COMPOUNDS; N-OXIDES; CONSTRUCTION; DERIVATIVES; INHIBITORS; CATALYSIS; BONDS;

D O I：

10.1039/d4ob01655f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel protocol for synthesizing 4-heteroaryl pyrazoles from readily available 2-aryl-3H-indoles and diazopyrazolones through the rhodium(iii)-catalyzed C-H bond activation has been achieved. This redox-neutral strategy features powerful reactivity, tolerates various functional groups, and proceeds with moderate yields under mild reaction conditions.

引用

页码：323 / 327

页数：5

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