Target-assisted self-cleavage DNAzyme electrochemical biosensor for MicroRNA detection with signal amplification

被引：0
|
作者：
Zhang, Juan [1 ]
Xie, Benting [1 ]
He, Haonan [1 ]
Gao, Hejun [1 ]
Liao, Fang [1 ]
Fu, Hongquan [1 ]
Liao, Yunwen [1 ]
机构：
[1] China West Normal Univ, Inst Appl Chem, Coll Chem & Chem Engn, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637000, Sichuan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 88期
关键词：
Compendex;
D O I：
10.1039/d4cc04190a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this work, we reported an electrochemical biosensor with target-assisted self-cleavage DNAzyme function for signal amplified detection of miRNA. The target-recycling amplification led to significant signal enhancement and thus offers high detection sensitivity. In this work, we reported an electrochemical biosensor with target-assisted self-cleavage DNAzyme function for signal amplified detection of miRNA.
引用
收藏
页码：12904 / 12907
页数：4
相关论文
共 50 条
  • [41] Electrochemical DNA biosensor based on proximity-dependent DNA ligation assays with DNAzyme amplification of hairpin substrate signal
    Sun, Chenhu
    Zhang, Liangliang
    Jiang, Jianhui
    Shen, Guoli
    Yu, Ruqin
    BIOSENSORS & BIOELECTRONICS, 2010, 25 (11): : 2483 - 2489
  • [42] Label-Free and Sensitive Electrochemical Biosensor for Amplification Detection of Target Nucleic Acids Based on Transduction Hairpins and Three-Leg DNAzyme Walkers
    Xue, Yu
    Wang, Yu
    Feng, Sinuo
    Yan, Mengxia
    Huang, Jianshe
    Yang, Xiurong
    ANALYTICAL CHEMISTRY, 2021, 93 (25) : 8962 - 8970
  • [43] 3D DNAzyme walker based electrochemical biosensor for attomolar level microRNA-155 detection
    Zhao, Jiaying
    He, Congjuan
    Long, Yanyi
    Lei, Jincan
    Liu, Huan
    Hou, Jingzhou
    Hou, Changjun
    Huo, Danqun
    ANALYTICA CHIMICA ACTA, 2023, 1276
  • [44] Cytidine-rich hydrogel as an electrochemical signal amplification strategy for microRNA detection
    Zhang, Xinying
    Zhang, Zhiwei
    Yang, Chujing
    Hu, Ziheng
    Chen, Yingying
    Feng, Lingyan
    ANALYST, 2022, 147 (12) : 2757 - 2763
  • [45] An Ultrasensitive Electrochemical Biosensor Integrated by Nicking Endonuclease-Assisted Primer Exchange Reaction Cascade Amplification and DNA Nanosphere-Mediated Electrochemical Signal-Enhanced System for MicroRNA Detection
    Yu, Sha
    Chen, Siyu
    Dang, Yuan
    Zhou, Yuanzhen
    Zhu, Jun-Jie
    ANALYTICAL CHEMISTRY, 2022, 94 (41) : 14349 - 14357
  • [46] An ultrasensitive label-free electrochemical biosensor for microRNA-21 detection based on a 2′-O-methyl modified DNAzyme and duplex-specific nuclease assisted target recycling
    Zhang, Xi
    Wu, Dongzhi
    Liu, Zhijing
    Cai, Shuxian
    Zhao, Yanping
    Chen, Mei
    Xia, Yaokun
    Li, Chunyan
    Zhang, Jing
    Chen, Jinghua
    CHEMICAL COMMUNICATIONS, 2014, 50 (82) : 12375 - 12377
  • [47] A low-noise ratiometric fluorescence biosensor for detection of Pb2+ based on DNAzyme and exonuclease III-assisted cascade signal amplification
    Jin, Huali
    Liu, Ruike
    Bai, Tian
    Wei, Min
    He, Baoshan
    Suo, Zhiguang
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2022, 414 (05) : 1899 - 1907
  • [48] Modified beacon probe assisted dual signal amplification for visual detection of microRNA
    Sun, Xiuwei
    Ying, Na
    Ju, Chuanjing
    Li, Zhongyi
    Xu, Na
    Qu, Guijuan
    Liu, Wensen
    Wan, Jiayu
    ANALYTICAL BIOCHEMISTRY, 2018, 550 : 68 - 71
  • [49] Engineering DNAzyme strategies for fluorescent detection of lead ions based on RNA cleavage-propelled signal amplification
    Li, Ying
    Liu, Kai
    Wang, Boxu
    Liu, Zheng
    Yang, Chuanyu
    Wang, Junyang
    Ma, Xinyue
    Li, Hongxia
    Sun, Chunyan
    JOURNAL OF HAZARDOUS MATERIALS, 2022, 440
  • [50] A "signal-on" electrochemical biosensor based on DNAzyme-driven bipedal DNA walkers and TdT-mediated cascade signal amplification strategy
    Lei, Sheng
    Liu, Zi
    Xu, Lingling
    Zou, Lina
    Li, Gaiping
    Ye, Baoxian
    ANALYTICA CHIMICA ACTA, 2020, 1100 (1100) : 40 - 46
12345