Efficient Synthesis and Iodine-Functionalization of Pyrazoles via KIO3/PhSeSePh System under Acidic Conditions

被引：1

作者：

Peglow, Thiago J. ^{[1
]}

Thomaz, Joao Pedro S. S. C. ^{[1
]}

Nobre, Patrick C. ^{[1
]}

Scimmi, Cecilia ^{[2
]}

Santi, Claudio ^{[2
]}

Nascimento, Vanessa ^{[1
]}

机构：

[1] Fed Univ Fluminense, Inst Chem, Dept Chem, SupraSelen Lab, Campus Valonguinho, BR-24020141 Niteroi, RJ, Brazil

[2] Univ Perugia, Dept Pharmaceut Sci, Grp Catalysis Synth & Organ Green Chem, Via Liceo 1, I-06123 Perugia, Italy

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2024年 / 19卷 / 23期

关键词：

Iodination; N-heterocycles; catalysis; selenium; IODINATION; HALOGENATION; MILD; ANILINES; FACILE;

D O I：

10.1002/asia.202400749

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This manuscript reports a novel method for the direct iodination of the C-4 pyrazole ring generated in situ by the reaction of 1,1,3,3-tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO3) is used as the iodinating agent and (PhSe)(2) is used as catalysts under acidic conditions. This protocol provides a convenient method for the efficient synthesis of 4-iodo-1-aryl-1H-pyrazoles, valuable intermediates for several different coupling reactions.

引用

页数：8

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