Innovative dissolving microneedles for enhanced delivery of alpha arbutin and ascorbic acid: a novel LC-MS quantification approach

被引：0

作者：

Tarawneh, Ola ^{[1
]}

Almasri, Sara ^{[1
]}

Alhusban, Ala A. ^{[1
]}

Hailat, Mohammad ^{[1
]}

Hamadneh, Lama ^{[2
]}

Abu Ershaid, Juhaina M. ^{[3
]}

Hailat, Zeyad ^{[4
]}

Makableh, Yahia F. ^{[5
]}

机构：

[1] Al Zaytoonah Univ Jordan, Fac Pharm, Amman, Jordan

[2] Al Balqa Appl Univ, Fac Med, As Salt, Jordan

[3] Isra Univ, Fac Pharm, Dept Appl Pharmaceut Sci & Clin Pharm, Amman, Jordan

[4] Yarmouk Univ, Dept Informat Syst, Irbid 21163, Jordan

[5] Jordan Univ Sci & Technol, Inst Nanotechnol, Irbid, Jordan

来源：

MATERIALS ADVANCES | 2025年 / 6卷 / 03期

关键词：

IN-VITRO; VALIDATION; ARRAYS; FILMS;

D O I：

10.1039/d4ma00908h

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This study presents a novel dissolving microneedles (MN) formulation designed to deliver alpha arbutin (AA) and ascorbic acid for hyperpigmentation treatment. Utilizing hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP-K90), we successfully prepared and characterized MN arrays with high drug loading efficiencies of 89.01% for AA and 94.09% for ascorbic acid. A pioneering liquid chromatography-tandem mass spectrometry (LC-MS) technique was developed for simultaneous drug quantification, achieving precision and accuracy as per FDA guidelines. Our MN demonstrated excellent mechanical properties, with effective skin penetration and dissolution within 5 minutes and permeation rates of 4.28% h-1 for AA and 3.61% h-1 for ascorbic acid. This innovative approach offers a promising platform for the transdermal delivery of active compounds, highlighting significant advancements in drug delivery technology.

引用

页码：1006 / 1019

页数：14

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