A gelatin/acrylamide-based hydrogel for smart drug release monitoring and radiation-induced wound repair in breast cancer

被引：0
作者：
Su, Ya [1 ,2 ]
Xu, Jie [1 ]
Liu, Wang [1 ]
Shu, Yan [1 ]
Ma, Hailin [1 ,3 ]
Cheng, Yuen Yee [4 ]
Liu, Yaqian [5 ]
Pan, Bo [5 ]
Song, Kedong [1 ,3 ]
机构：
[1] State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian
[2] Institute of Rehabilitation Medicine, Henan Academy of Innovations in Medical Science, Central Plains Medical Science City, Zhengzhou Airport Area, Henan
[3] Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou
[4] Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, 2007, NSW
[5] Department of Breast Surgery, The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Liaoning, Dalian
来源：
International Journal of Biological Macromolecules | 2024年 / 283卷
基金：
中国国家自然科学基金;
关键词：
Breast cancer; Double-network hydrogel; Drug release; Localized radiotherapy; Wound repair;
D O I：
10.1016/j.ijbiomac.2024.137845
中图分类号：
学科分类号：
摘要：
Radiotherapy is a common local treatment for breast cancer, and while it is effective in targeting tumor cells, it inevitably causes significant side effects. These include excessive production of reactive oxygen species (ROS), repeated inflammatory, and severe skin ulceration, all of which can hinder the wound healing process. As a result, there is a pressing need for multifunctional medical dressings that can support wound repair following radiotherapy. In this study, we introduced a novel double-network interpenetrating hydrogel (GEMC), which combined gelatin grafted dopamine (GEDA), acrylamide, nano-clay (NC), and curcumin loaded nanoparticles (CCNPs). Unlike traditional single-function hydrogels, the GEMC hydrogel offered a combination of antioxidant properties, tissue adhesion, and real time drug tracking, effectively addressing the multifaceted challenges of wound healing after radiotherapy. The GEMC hydrogel exhibited impressive antioxidant activity and superior mechanical properties, which collectively improve the support and protection of wounded surfaces. Furthermore, GEMC promoted skin regeneration, angiogenesis and reduced inflammatory in a mouse model of radiotherapy-induced skin ulceration. These results highlight the hydrogel's potential to accelerate would healing and enhance the effectiveness of post-radiotherapy wound care, providing a promising new approach to improving the quality of skin recovery following radiotherapy. © 2024 Elsevier B.V.
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