A Multi-Responsive Hydrogel Combined With Mild Heat Stimulation Promotes Diabetic Wound Healing by Regulating Inflammatory and Enhancing Angiogenesis

被引：3

作者：

Dai, Fanjia ^{[1
,2
]}

Zhang, Jiaying ^{[1
]}

Chen, Fengjiao ^{[1
]}

Chen, Xianwu ^{[3
]}

Lee, Celine Jessica ^{[4
]}

Liang, Hongze ^{[1
]}

Zhao, Lingling ^{[1
]}

Tan, Hui ^{[2
]}

机构：

[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Peoples R China

[2] Shantou Univ, Shenzhen Childrens Hosp, Med Coll, Ctr Child Care & Mental Hlth, Shenzhen 518026, Peoples R China

[3] Ningbo Univ, Affiliated Hosp, Med Sch, Ningbo 315211, Peoples R China

[4] Queensland Childrens Hosp, Brisbane, QLD 4101, Australia

来源：

ADVANCED SCIENCE | 2024年 / 11卷 / 46期

关键词：

angiogenesis; anti-inflammatory; antioxidant; diabetic wound healing; hydrogel dressing; mild heat stimulation; GLYCOL CHITOSAN; C-DOMAIN; ANTIBACTERIAL; DRESSINGS; MICELLES; THERAPY;

D O I：

10.1002/advs.202408783

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The repair of diabetic wound still encounters huge challenges, such as disordered inflammatory regulation and impaired neovascularization. Here, a pH/ROS/glucose responsive and photothermal hydrogel is developed for diabetic wound healing. The hydrogel is formed through cross-linkage between phenylboronic acid-modified carboxymethyl chitosan (CMCS-PBA) and oxide dextran (OXD), utilizing Schiff base and phenylboronate ester bonds. Additionally, insulin-like growth factor 1 C domain (IGF-1C) and deferoxamine-loaded polydopamine nanoparticles (D@P) are incorporated into the hydrogel. The hydrogel demonstrates sustained drug release, excellent photo thermal effect, prominent antioxidant, antibacterial and anti-inflammatory activities, desirable mechanical and tissue adhesive properties, enhanced tube formation, and cell migration. Furthermore, the hydrogel combined with mild heat treatment can regulate chronic inflammation by promoting the transformation of macrophages from M1 phenotype to M2 phenotype and enhance angiogenesis by up-regulating the expression levels of angiogenesis-related factors such as hypoxia-inducible factor-1 alpha (HIF-1 alpha), vascular endothelial growth factor (VEGF), CD31, and alpha-SMA, thus greatly accelerates the wound healing in streptozotocin (STZ)-induced diabetic mice. Therefore, this multi-responsive and multifunctional hydrogel holds potential as a therapeutic strategy for diabetic wounds. A pH/ROS/glucose multi-responsive composite hydrogel with good photothermal effect, and antioxidant, and anti-inflammatory properties is designed for diabetic wound healing. The hydrogel combined with mild heat treatment can regulate chronic inflammation by promoting the M1/M2 macrophage transformation in vivo, promote angiogenesis by up-regulating the expression levels of HIF-1 alpha, VEGF, CD31, and alpha-SMA, and thus accelerate the diabetic wound healing. image

引用

页数：18

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