Windows of susceptibility and joint effects of prenatal and postnatal ambient air pollution and temperature exposure on asthma and wheeze in Mexican children

被引：1

作者：

Hu, Cheng-Yang ^{[1
,2
]}

Gutierrez-Avila, Ivan ^{[1
]}

He, Mike Z. ^{[1
]}

Lavigne, Eric ^{[3
,4
]}

Alcala, Cecilia S. ^{[1
]}

Yitshak-Sade, Maayan ^{[1
]}

Lamadrid-Figueroa, Hector ^{[5
]}

Tamayo-Ortiz, Marcela ^{[6
]}

Mercado-Garcia, Adriana ^{[7
]}

Just, Allan C. ^{[8
]}

Gennings, Chris ^{[1
]}

Tellez-Rojo, Martha ^{[7
]}

Wright, Robert O. ^{[1
,9
,10
]}

Wright, Rosalind J. ^{[1
,9
,10
]}

Rosa, Maria Jose ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Environm Med & Climate Sci, One Gustave L Levy Pl,Box 1057, New York, NY 10029 USA

[2] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Peoples R China

[3] Hlth Canada, Populat Studies Div, 269 Laurier Ave West, Ottawa, ON K1A 0K9, Canada

[4] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[5] Natl Inst Publ Hlth INSP, Ctr Populat Hlth Res, Dept Perinatal Hlth, Av Univ 655 Col Santa Maria Ahuacatitlan, Cuernavaca 62100, Morelos, Mexico

[6] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA

[7] Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Av Univ 655 Col Santa Maria Ahuacatitlan, Cuernavaca 62100, Morelos, Mexico

[8] Brown Univ, Sch Publ Hlth, Dept Epidemiol, 121 S Main St, Providence, RI 02903 USA

[9] Icahn Sch Med Mt Sinai, Dept Publ Hlth, 1184 Fifth Ave, New York, NY 10029 USA

[10] Icahn Sch Med Mt Sinai, Inst Climate Change Environm Hlth & Expos, One Gustave L Levy Pl,Box 1057, New York, NY 10029 USA

来源：

ENVIRONMENT INTERNATIONAL | 2024年 / 193卷

关键词：

Air pollution; Temperature; Asthma; Wheeze; Susceptible window; EARLY-LIFE EXPOSURE; LUNG-FUNCTION; ENVIRONMENTAL-FACTORS; RESPIRATORY SYMPTOMS; CHILDHOOD ASTHMA; CLIMATE-CHANGE; SEX; HEALTH; IMPACT; RISK;

D O I：

10.1016/j.envint.2024.109122

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Introduction: Prenatal and early-life exposure to air pollution and extreme temperatures are associated with childhood asthma and wheeze. However, potential windows of susceptibility and their sex-specific and interactive effects have not been fully elucidated. We aimed to identify critical windows of susceptibility and evaluate sex-specific effects in these associations, and evaluate exposure interactions. Methods: We analyzed data from 468 mother-child pairs enrolled in the PROGRESS birth cohort in Mexico City. Daily residential levels of PM2.5, NO2, and temperature were generated from our validated spatiotemporally resolved models from conception to age 4 years. Childhood asthma and wheeze outcomes were collected at 4-6 and 7-8 years. Distributed lag nonlinear models (DLNMs) were used to identify susceptible windows for prenatal weekly-specific and postnatal monthly-specific associations of air pollution and temperature with respiratory outcomes adjusting for covariates. To evaluate sex-specific effects, DLNMs were stratified. Joint effects were assessed using relative excess risk due to interaction and attributable proportion. Results: Mid-gestation was a critical window for both PM 2.5 (weeks 20-28, cumulative OR: 1.18 [95% CI: 1.01, 1.37]; weeks 19-26, cumulative OR: 1.18 [95% CI: 1.02, 1.36]) and NO2 (weeks 18-25, cumulative OR: 1.16 [95% CI: 1.02, 1.31]) exposure, associated with higher odds of wheeze. Postnatal exposure to PM 2.5 and NO2 during the first year of life was also linked to higher odds of wheeze. The warmer and colder temperatures showed mixed effects on respiratory outcomes. We observed a synergistic interaction between high PM 2.5 and high temperature exposure during the first year of life, associated with higher odds of current wheeze. The associations of prenatal air pollution and temperature exposure with respiratory outcomes were more pronounced in males.

引用

页数：13