Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte-myofibroblast transition in epidural fibrosis

被引：1

作者：

Hua, Feng ^{[1
]}

Sun, Jinpeng ^{[1
]}

Shi, Mohan ^{[1
]}

Mei, Rui ^{[1
]}

Song, Zeyuan ^{[1
]}

Liu, Jun ^{[1
]}

Zhang, Mingshun ^{[2
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 2, Dept Orthoped, Nanjing, Peoples R China

[2] Nanjing Med Univ, Jiangsu Prov Engn Res Ctr Antibody Drug, Dept Immunol, NHC Key Lab Antibody Tech, Nanjing, Peoples R China

来源：

NPJ REGENERATIVE MEDICINE | 2024年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

FATTY LIVER-DISEASE; MANAGEMENT; PROTECTS; OBESITY;

D O I：

10.1038/s41536-024-00388-6

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Epidural fibrosis post laminectomy is the leading cause of failed back surgery syndrome. Little is known about the role and mechanisms of adipose tissues in epidural fibrosis. Here, we found that obese patients were more likely to develop epidural fibrosis after spine surgery. Similarly, obesity led to more progressive epidural fibrosis in a mouse model of laminectomy. Adipocyte-myofibroblast transition (AMT) occurs in epidural scarring. Mechanistically, large extracellular vesicles (EVs) from M2-type macrophages transfer mitochondria into adipocytes and promote AMT by activating the TGF-beta and PAI-1 pathways. Blocking the PAI-1 pathway significantly attenuated the transition of adipocytes into myofibroblasts. We conclude that large EVs from macrophages transfer mitochondria to promote AMT in epidural fibrosis.

引用

页数：14

共 52 条

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