Transcriptome profiling research in urothelial cell carcinoma

被引：0

作者：

Ahmad, Umar ^{[1
,2
]}

Ibrahim, Buhari ^{[3
,4
]}

Mohammed, Mustapha ^{[5
,6
]}

Aldoghachi, Ahmed Faris ^{[7
]}

Usman, Mahmood ^{[8
,9
]}

Yakubu, Abdulbasit Haliru ^{[10
,11
]}

Tanko, Abubakar Sadiq ^{[12
]}

Bobbo, Khadijat Abubakar ^{[13
,14
]}

Garkuwa, Usman Adamu ^{[4
,15
]}

Faggo, Abdullahi Adamu ^{[16
]}

Mustapha, Sagir ^{[17
]}

Al-Masaeed, Mahmoud ^{[18
,19
]}

Abdullah, Syahril ^{[7
,13
]}

Keong, Yong Yoke ^{[20
]}

Veerakumarasivam, Abhi ^{[21
]}

机构：

[1] Bauchi State Univ, Fac Basic Med Sci, Dept Anat, Mol Genet Informat, PMB 65, Gadau, Bauchi, Nigeria

[2] African Union Commiss, Africa Ctr Dis Control & Prevent Africa CDC, Div Lab Syst & Networks, Inst Pathogen Genom, Addis Ababa, Ethiopia

[3] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Imaging, Serdang, Selangor, Malaysia

[4] Bauchi State Univ, Fac Basic Med Sci, Dept Physiol, Gadau, Bauchi, Nigeria

[5] Ahmadu Bello Univ, Fac Pharmaceut Sci, Dept Clin Pharm & Pharm Practice, Kaduna, Nigeria

[6] Qatar Univ, Med & Hlth Sci Off, QU Hlth, Doha, Qatar

[7] Univ Putra Malaysia, Fac Med & Hlth Sci, Genet & Regenerat Med Res Ctr, Med Genet Lab, Serdang 43400, Selangor, Malaysia

[8] Ahmadu Bello Univ, Fac Basic Med Sci, Dept Human Anat, Zaria, Kaduna, Nigeria

[9] Yusuf Maitama Sule Univ, Fac Basic Sci, Dept Human Anat, Kano, Nigeria

[10] Univ Maiduguri, Fac Pharm, Maiduguri, Borno, Nigeria

[11] Univ Maiduguri, Pharmaceut Serv, Teaching Hosp, Maiduguri, Borno, Nigeria

[12] Bauchi State Univ, Dept Biochem, Gadau, Nigeria

[13] Univ Putra Malaysia, Inst Biosci, UPM MAKNA Canc Res Lab, Serdang, Selangor, Malaysia

[14] Gombe State Univ, Fac Basic Med Sci, Dept Anat, Gombe, Nigeria

[15] Ahmadu Bello Univ, Fac Basic Med Sci, Dept Human Physiol, Zaria, Kaduna, Nigeria

[16] Bauchi State Univ Gadau BASUG, Fac Sci, Gadau, Bauchi State, Nigeria

[17] Univ Sains Malaysia, Kota Bharu Kelantan, Malaysia

[18] Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia

[19] Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang, Selangor, Malaysia

[20] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang, Selangor, Malaysia

[21] Sunway Univ, Sch Healthcare & Med Sci, Dept Med Sci, Bandar Sunway, Selangor, Malaysia

来源：

APPLIED RESEARCH | 2024年 / 3卷 / 03期

关键词：

bioinformatics; bladder cancer; genomics; RNA-sequencing; transcriptome profiling; RNA SEQUENCING REVEALS; BLADDER-CANCER; EXPERIMENTAL-DESIGN; EXPRESSION ANALYSIS; MICROARRAY DATA; QUALITY-CONTROL; SEQ REVEALS; BIOMARKERS; GENE; INTEGRATION;

D O I：

10.1002/appl.202300002

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Urothelial cell carcinoma (UCC) is the ninth most common cancer that accounts for 4.7% of all new cancer cases globally. UCC development and progression are due to complex and stochastic genetic programs. To study the cascades of molecular events underlying the poor prognosis that may lead to limited treatment options for advanced disease and resistance to conventional therapies in UCC, transcriptomics technology (RNA-Seq), a method of analyzing the RNA content of a sample using modern high-throughput sequencing platforms has been employed. Here, we review the principles of RNA-Seq technology and summarize recent studies on human bladder cancer that employed this technique to unravel the pathogenesis of the disease, identify biomarkers, discover pathways and classify the disease state. We list the commonly used computational platforms and software that are publicly available for RNA-Seq analysis. Moreover, we discussed the future perspectives for RNA-Seq studies on bladder cancer and recommended the application of a new technology called single-cell sequencing to further understand the disease.

引用

页数：13

共 137 条

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