Manufacturing of a 3D-printed electrode cost-effective based on carbon black and polylactic acid for detection of flunixin anti-inflammatory

被引：1

作者：

Silva, Francisco Walison Lima ^{[1
]}

Rodrigues, Jose Guilherme Aquino ^{[2
,3
]}

Ferreira, Rafael de Queiroz ^{[2
]}

de Freitas, Jair Carlos Checon ^{[3
]}

Santelli, Ricardo Erthal ^{[1
,4
]}

Cincotto, Fernando Henrique ^{[1
,4
]}

机构：

[1] Univ Fed Rio de Janeiro, Dept Quim Analit, Inst Quim, Rio De Janeiro, Brazil

[2] Univ Fed Espirito Santo, Ctr Exact Sci, Chem Dept, Electrochem Res & Dev Lab, Vitoria, ES, Brazil

[3] Univ Fed Espirito Santo, Ctr Exact Sci, Phys Dept, Lab Carbon & Ceram Mat, Vitoria, ES, Brazil

[4] Natl Inst Sci & Technol Bioanalyt INCTBio, Campinas, Brazil

来源：

ELECTROCHIMICA ACTA | 2024年 / 507卷

关键词：

3D-printed sensor; Flunixin; Electrode activation; Voltammetric analyses; Polylactic acid and carbon black; ELECTROCHEMICAL SENSORS; MEGLUMINE; RESIDUES; IDENTIFICATION; METABOLITE; PLASMA; CELLS;

D O I：

10.1016/j.electacta.2024.145117

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

This study presents the manufacturing and application of a 3D-printed sensor based on CB/PLA for detecting the anti-inflammatory drug flunixin (FXN). The proposed sensor features a simple design and accessible construction process with fast production (similar to 25 min), fast activation (similar to 400 s), low cost (similar to 0.044 USD), and stands out for its sensitivity (0.083 mu A mu mol L-1) and low detection limit (0.30 mu mol L-1). Furthermore, the sensor presents allowed the determination of the FXN in real samples such as pharmaceutical formulations (tablet and injectable), tap and river water without pretreatment. The selectivity obtained was satisfactory in the presence of metal ions and organic compounds. The results showed that the use of 3D printing technology with fast surface treatment made it possible to study the anti-inflammatory behavior of FXN in a satisfactory way. Therefore, it is pertinent to use 3D technology in electrochemical analyses of potential antibiotics and other pharmaceuticals.

引用

页数：8