Vascular protection by high-density lipoprotein-associated sphingosine-1-phosphate

被引：0

作者：

Xi WANG

Fan WANG

机构：

[1] DepartmentofGeriatricCardiology,ChinesePLAGeneralHospital

来源：

Journal of Geriatric Cardiology | 2017年 / 14卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

摘要：

Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein(HDL). Findings from a growing number of studies further indicate that sphingosine-1-phosphate(SIP) mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protection against atherosclerosis and ischemia/reperfusion injury. In this review, we summarize the most recent literature investigating the effects of HDL-S1P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.

引用

页码：696 / 702

页数：7

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