Iontophoretic transdermal delivery of angiotensin II and its antagonists

Angiotensin II and its antagonists were used as permeant probes to investigate tile mechanism of transdermal iontophoretic delivery of peptide/protein drugs and compare the effect of hydrophobic difference between the peptides drugs on the skin permeability. Transport of angiotensin II and its antagonists through excised rabbit pinna skin were enhanced with iontophoresis by monophase periodically pulsed current, amplituide= 1mA, frequency= 1000Hz and on/off ratio equals 50%. Tile delivery rate was proportional both to tile current intensity and pulse duration of tile stimulation. Results showed that tile permeation rate of [Sar, Ile] Angiotensin II > [Sar, Ala]Angiotensin II > Angiotensin II. Iontophoretic mobility and hydrophobicity were tile key factors dominating tile transdermal iontophoretic delivery rate of angiotensin II and its antagonists.