Low expression of nm23-H1 mRNA and its protein in breast cancer

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作者：
Guo, Wenbin
Wang, Yanxia
Zhuang, Xijing
Bai, Yan
Zhang, Jiaqing
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Zhonghua Yixue Yichuanxue Zazhi/Chinese Journal of Medical Genetics | 2000年 / 17卷 / 02期
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摘要：
Objective: To explore the expression of nm23-H1 mRNA and its protein in breast cancer and its correlation to the biologic behavior. Methods: RT-PCR and immmunohistochemical method were employed to detect the expression of nm23-H1 mRNA and its protein in 58 breast cancer tissues. Results: Low level expression of nm23-H1 mRNA and protein was shown in 44.8% and 48.2% of examinated cases respectively. The low expression of nm23-H1 mRNA was correlated, but not always parallel to the protein expression. The low level expression of nm23-H1 mRNA or the protein was significantly associated with lymphatic metastasis of the cancer. Conclusion: Examination of nm23-H1 expression may be of significance in evaluating metastatic potentiality and prognosis of breast cancer.
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页码：91 / 93
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