Parameter estimation of an enzyme kinetic system using computer algebra techniques

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Appl Math Comput (New York) | / 1卷 / 93-98期

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A procedure for fitting enzyme kinetic data directly to the flux equation was described. It involves choosing parameters that minimize the sum of the squares of deviations due to errors in s, the substrate concentration at time t. Estimates of the standard errors of the parameters are provided using computer algebra and numerical analysis techniques.

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