Acylation of sugar hydroxyl groups with N-Boc amino acid N- carboxyanhydrides (Boc-NCAs). Synthesis of amino acid-saccharide conjugates

被引：0

作者：

SIRCOB, Université de Versailles, Bât. Lavoisier, 45 avenue des Etats Unis, F-78000 Versailles, France ^{[1
]}

不详 ^{[2
]}

机构：

来源：

Synth. Commun. | / 14卷 / 2713-2724期

关键词：

Dichloromethane;

D O I：

暂无

中图分类号：

O62 [有机化学]; TQ [化学工业];

学科分类号：

070303 ; 0817 ; 081704 ;

摘要：

Boc-NCAs cleanly react with a series of free or protected sugars to give mono- or poly-amino acid conjugates in good yields. Trifluoroacetic acid in methylene chloride only cleaves the N-Boc protecting group. Treatment with aqueous trifluoroacetic acid removes the remaining isopropylidene protecting groups and leads to free glycoconjugates.

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