Determination of racecadotril and its impurities by HPLC

被引：0
|
作者：
Zhao, Z. [1 ]
Liu, S.-C. [1 ]
机构：
[1] Tianjin Munic. Inst. for Drug Ctrl., Tianjin 300070, China
来源：
Chinese Pharmaceutical Journal | 2001年 / 36卷 / 04期
关键词：
Acetonitrile - Benzene - Mixtures - Potassium compounds - Regression analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
OBJECTIVE: A HPLC method was established for the determination of racecadotril and its impurities. METHODS: A ODS column was used and the mixture of acetonitrile-potassium dihydrogen phosphate (KH2PO4) solution (70:30) was used as the mobile phase. The detection wavelength was 210 nm. RESULTS: The liner range of the racecadotril was 0.08∼0.24 mg&middotmL-1 and the regression equation was Y = 15847X + 3873(r = 0.9997). The liner range of benzylthiorphan disulphide was 2.40∼21.56 μg&middotmL-1 and the regression equation was Y = 1826x + 46 (r = 0.9999). The measurable lowest limit was 1 μg&middotmL-1. The average recovery was 100.0%. CONCLUSION: The method was convenient, accurate and specific.
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页码：267 / 269
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