Deuteration of indole and N-methylindole by Raney nickel catalysis

被引：0
|
作者：
Yau, Wai-Ming [1 ]
Gawrisch, Klaus [1 ]
机构：
[1] LMBB, NIAAA, NIH, 12420 Parklawn Dr., Rockville, MD 20852, United States
来源：
Journal of Labelled Compounds and Radiopharmaceuticals | 1999年 / 42卷 / 07期
关键词：
Deuterated solvents - Deuterations - Indole - Isopropanol - N-methylindole - Nickel catalysis - Raney nickel - Research tools - Solid state NMR - Specific sites;
D O I：
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学科分类号：
摘要：
Indole and N-methylindole have been partially or fully deuterated by Raney nickel catalyzed 1H-2H exchange in a series of deuterated solvents. Perdeuterated indoles have been obtained in water and methanol while compounds that are preferentially deuterated at specific sites were obtained in chloroform, acetone, acetonitrile, ethanol, and isopropanol. The partially deuterated compounds are an important research tool for solid-state NMR studies on proteins.
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页码：709 / 714
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