The electro-ion microclimate is a component of environment formed by negative and positive ions in the atmosphere - so-called aeroions - which man is exposed to and which influence his overall condition. In this paper, the authors measured the level of the electro-ionic microclimate in buildings built: (a) of conventional materials (bricks, wood), (b) from slag concrete panels, (c) from lightweight concrete outside walls. A statistical analysis of the measured data shows that the level of electro-ionic microclimate expressed by lightweight negative u//i** minus and positive u//i** plus ion concentration depends on the level of electro-ionic microclimate in the exterior (u//e** minus , u//e** plus ) as well as on the partial water vapor pressure in the interior.