The antiestrogen [2-(4-benzyl-phenoxy)ethyl]diethylammonium chloride

被引：1

作者：

Hempel, Andrew ^{[1
]}

Camerman, Norman ^{[1
]}

Dauter, Zbigniew ^{[2
]}

Mastropaolo, Donald ^{[3
]}

Camerman, Arthur ^{[3
]}

机构：

[1] Department of Biochemistry, University of Toronto, Medical Sciences Building, Toronto,M5S 1A8, Canada

[2] National Cancer Institute, Frederick and Brookhaven National Laboratory, NSLS, Building 725A-X9, Upton,NY,11973, United States

[3] Ardono Research, 8515C 35 Ave. NE, Seattle,WA,98115, United States

来源：

Acta Crystallographica Section C: Crystal Structure Communications | 2000年 / 56卷 / 04期

关键词：

Binding sites - Cancer cells - Chlorine compounds - Diseases;

D O I：

10.1107/S0108270199016741

中图分类号：

学科分类号：

摘要：

[2-(4-benzylphenoxy)ethyl]diethylammonium chloride was a diphenylmethane analogue of the antiestrogen tamoxifen which antagonizes the binding of histamine to intracellular growth-regulatory sites associated with antiestrogen-binding sites in microsomes and nuclei. It Was found that >[2-(4-benzylphenoxy)ethyl]diethylammonium chloride increased the therapeutic index of some chemotherapy drugs, with the added benefit of lower toxicity to normal tissue such as bone marrow, gut and hair, and the compound was studied as a treatment for metastatic prostate cancer. A chemopotentiating effect of the drug in patients with early metastatic breast cancer has was also observed along with growth-inhibitory effects on human ovarian cancer cells when combined with cisplatin.

引用

页码：455 / 456