The Total Synthesis of (+)-Hapalindole Q by an Organomediated Diels-Alder Reaction

被引：0

作者：

Kinsman, Aaron C. ^{[1
]}

Kerr, Michael A. ^{[1
]}

机构：

[1] Department of Chemistry, University of Western Ontario, London, Ont. N6A 5B7, Canada

来源：

Journal of the American Chemical Society | 2003年 / 125卷 / 46期

关键词：

Catalysts; -; Stereochemistry;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The total synthesis of (+)-hapalindole Q has been achieved. The key step is a Diels-Alder reaction mediated by MacMillan's organocatalyst to provide the critical intermediate with high enantiose-lectivity (93% ee). This step establishes the proper arrangement of the required four contiguous stereocenters, including the quaternary center, and represents the first successful application of an enantioselective organomediated Diels-Alder reaction in total synthesis.

引用

页码：14120 / 14125

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