Kinetics and mechanism of the reaction of alkaline hydrolysis of Reumicin

被引：0
|
作者：
Shorshnev, S.V. [1 ]
Chernyshev, A.I. [1 ]
Esipov, S.E. [1 ]
机构：
[1] All-Union Scientific-Research Inst, of Antibiotics, Russia
来源：
Kinetics and Catalysis | 1988年 / 29卷 / 1 pt 1期
关键词：
Chemical Reactions - Reaction Kinetics;
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摘要：
The kinetics of alkaline hydrolysis of the antibiotic Reumicin were investigated by 1H NMR spectroscopy. The mechanism of the reaction was proposed, which includes the reversible formation of the adduct of Reumicin with the hydroxyl ion and the subsequent transformation of the intermediate into the final product: the 6-(3-methyl-ureido)-1,2,4-triazine-5-carboxylic acid anion. The kinetic scheme satisfies the experimental data.
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页码：57 / 60
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