Self-consistent simulations of electroporation dynamics in biological cells subjected to ultrashort electrical pulses

被引：61
|
作者：
Joshi, R.P. [1 ,1 ]
Hu, Q. [1 ,1 ]
Aly, R. [1 ,1 ]
Schoenbach, K.H. [1 ,1 ]
Hjalmarson, H.P. [1 ,1 ]
机构：
[1] Dept. of Elec. and Comp. Eng., Old Dominion University, Norfolk, VA 23529-0246, United States
来源：
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | 2001年 / 64卷 / 1 I期
关键词：
Bessel functions - Cell membranes - Cells - Computer simulation - Electrophysiology - Hydrophilicity - Hydrophobicity - Mathematical models - Porous materials - Surface tension;
D O I：
10.1103/PhysRevE.64.011913
中图分类号：
学科分类号：
摘要：
A self-consistent model analysis of electroporation in biological cells was carried out based on the coupled Laplace-Nernst-Planck-Smoluchowski equations. The physical processes of pore generation, drift, and diffusion in r space were all comprehensively included. A pore-radius-dependent energy barrier to ionic transport accounted for cellular variations. As a result, predictions and qualitative understanding of the cellular response to short, high electric field pulses were obtained.
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收藏
页码：1 / 011913
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