Self-consistent simulations of electroporation dynamics in biological cells subjected to ultrashort electrical pulses

被引：61

作者：

Joshi, R.P. ^{[1
,1
]}

Hu, Q. ^{[1
,1
]}

Aly, R. ^{[1
,1
]}

Schoenbach, K.H. ^{[1
,1
]}

Hjalmarson, H.P. ^{[1
,1
]}

机构：

[1] Dept. of Elec. and Comp. Eng., Old Dominion University, Norfolk, VA 23529-0246, United States

来源：

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | 2001年 / 64卷 / 1 I期

关键词：

Bessel functions - Cell membranes - Cells - Computer simulation - Electrophysiology - Hydrophilicity - Hydrophobicity - Mathematical models - Porous materials - Surface tension;

D O I：

10.1103/PhysRevE.64.011913

中图分类号：

学科分类号：

摘要：

A self-consistent model analysis of electroporation in biological cells was carried out based on the coupled Laplace-Nernst-Planck-Smoluchowski equations. The physical processes of pore generation, drift, and diffusion in r space were all comprehensively included. A pore-radius-dependent energy barrier to ionic transport accounted for cellular variations. As a result, predictions and qualitative understanding of the cellular response to short, high electric field pulses were obtained.

引用

页码：1 / 011913