Synthesis of new sulfonamide inhibitors of carbonic anhydrase

被引：0

作者：

Arslan, O. ^{[1
]}

Cakir, U. ^{[1
]}

Uorap, H.Y. ^{[1
]}

机构：

[1] Balikesir Univ., Balikesir, 10100, Turkey

来源：

Biokhimiya | 2002年 / 67卷 / 09期

关键词：

Aromatic compounds - Enzymes - Sulfur compounds - Synthesis (chemical);

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Four different derivatives of aromatic sulfonamides have been synthesized: 1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane (SBAM), 1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane, 1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane, and 1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)ethoxy]ethane. SBAM is a most potent inhibitor on ciliary epithelium carbonic anhydrase and is approximately 13 times more active against carbonic anhydrase isoform II than against isoform I.

引用

页码：1273 / 1276

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