Synthesis of new sulfonamide inhibitors of carbonic anhydrase

被引：0
|
作者：
Arslan, O. [1 ]
Cakir, U. [1 ]
Uorap, H.Y. [1 ]
机构：
[1] Balikesir Univ., Balikesir, 10100, Turkey
来源：
Biokhimiya | 2002年 / 67卷 / 09期
关键词：
Aromatic compounds - Enzymes - Sulfur compounds - Synthesis (chemical);
D O I：
暂无
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学科分类号：
摘要：
Four different derivatives of aromatic sulfonamides have been synthesized: 1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane (SBAM), 1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane, 1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane, and 1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)ethoxy]ethane. SBAM is a most potent inhibitor on ciliary epithelium carbonic anhydrase and is approximately 13 times more active against carbonic anhydrase isoform II than against isoform I.
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页码：1273 / 1276
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