Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes

被引：0
|
作者：
机构：
来源：
J Biol Chem | / 28卷 / 17491期
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver
    Roncero, Isabel
    Alvarez, Elvira
    Acosta, Carlos
    Sanz, Carmen
    Barrio, Pedro
    Hurtado-Carneiro, Veronica
    Burks, Deborah
    Blazquez, Enrique
    PLOS ONE, 2013, 8 (04):
  • [32] Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation
    Miki, H
    Yamauchi, T
    Suzuki, R
    Komeda, K
    Tsuchida, A
    Kubota, N
    Terauchi, Y
    Kamon, J
    Kaburagi, Y
    Matsui, J
    Akanuma, Y
    Nagai, R
    Kimura, S
    Tobe, K
    Kadowaki, T
    MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (07) : 2521 - 2532
  • [33] A pivotal role of IRS-1/IRS-2 in insulin-stimulated protein synthesis pathway
    Tobe, K
    Yamauchi, T
    Tamemoto, H
    Akanuma, Y
    Yazaki, Y
    Kadowaki, T
    DIABETES, 1996, 45 : 914 - 914
  • [34] Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
    Midori Honma
    Shojiro Sawada
    Yoshiyuki Ueno
    Keigo Murakami
    Tetsuya Yamada
    Junhong Gao
    Shinjiro Kodama
    Tomohito Izumi
    Kei Takahashi
    Sohei Tsukita
    Kenji Uno
    Junta Imai
    Eiji Kakazu
    Yasuteru Kondo
    Kei Mizuno
    Naoki Kawagishi
    Tooru Shimosegawa
    Hideki Katagiri
    International Journal of Obesity, 2018, 42 : 1544 - 1555
  • [35] Dual knockdown of IRS-1 and IRS-2 in liver exacerbates insulin resistance to cause diabetes
    Taniguchi, CM
    Ueki, K
    Kahn, CR
    DIABETES, 2005, 54 : A340 - A341
  • [36] A molecular basis for insulin resistance: Elevated Ser/Thr phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor (IR) and impairs their ability to undergo insulin-induced Tyr phosphorylation.
    Kanety, H
    Paz, K
    Hemi, R
    Karasik, A
    Zick, Y
    DIABETOLOGIA, 1997, 40 : 557 - 557
  • [37] TNFalpha impairs insulin signaling in pancreatic beta-cells through JNK-dependent serine phosphorylation of IRS-2
    Montrone, C
    Natalicchio, A
    Martemucci, S
    Perrini, S
    Caccioppoli, C
    Laviola, L
    Giorgino, R
    Giorgino, F
    DIABETOLOGIA, 2004, 47 : A178 - A178
  • [38] Gene expression explains IRS-2, but not IRS-1, depletion in glucose- and insulin-induced insulin resistance
    Renström, F
    Burén, J
    Eriksson, JW
    DIABETES, 2004, 53 : A315 - A315
  • [39] Phosphorylation of selected serines in the PTB domain of IRS-2 inhibits its function and promotes insulin resistance under pathological conditions
    Gurevitch, Diana
    Bura-Halfon, Sigalit
    Ronen, Denise
    Zick, Yehiel
    FASEB JOURNAL, 2007, 21 (05): : A293 - A293
  • [40] Insulin-induced Insulin Resistance in β-Cell-specific IRS-2 Knockout Mice
    Hall, Ben A.
    Demozay, Damien
    Alarcon, Cristina
    Boland, Brandon
    White, Morris F.
    Rhodes, Christopher J.
    DIABETES, 2014, 63 : A12 - A12
12345