Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes

被引:0
|
作者
机构
来源
J Biol Chem | / 28卷 / 17491期
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    Paz, K
    Hemi, R
    LeRoith, D
    Karasik, A
    Elhanany, E
    Kanety, H
    Zick, Y
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (47) : 29911 - 29918
  • [22] IRS-2 differs from IRS-1 in insulin-induced tyrosine phosphorylation and activation of PI 3-kinase.
    Ogihara, T
    Funaki, M
    Katagiri, H
    Oka, Y
    Yazaki, Y
    Asano, T
    DIABETES, 1996, 45 : 435 - 435
  • [23] Adenoviral-mediated RNA interference reveals the relative roles of IRS-1 and IRS-2 in hepatic insulin action
    Taniguchi, CM
    Ueki, K
    Kahn, CR
    DIABETES, 2004, 53 : A37 - A37
  • [24] The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action
    Sun, XJ
    Pons, S
    Wang, LM
    Zhang, YT
    Yenush, L
    Burks, D
    Myers, MG
    Glasheen, E
    Copeland, NG
    Jenkins, NA
    Pierce, JH
    White, MF
    MOLECULAR ENDOCRINOLOGY, 1997, 11 (02) : 251 - 262
  • [25] Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    Kido, Y
    Burks, DJ
    Withers, D
    Bruning, JC
    Kahn, CR
    White, MF
    Accili, D
    JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (02): : 199 - 205
  • [26] The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2
    Hanke, Stefan
    Mann, Matthias
    MOLECULAR & CELLULAR PROTEOMICS, 2009, 8 (03) : 519 - 534
  • [27] Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2
    Dearth, Robert K.
    Cui, Xiaojiang
    Kim, Hyun-Jung
    Hadsell, Darryl L.
    Lee, Adrian V.
    CELL CYCLE, 2007, 6 (06) : 705 - 713
  • [28] IRS-2 is a common element in peripheral insulin signaling and β-cell function
    White, M
    MOLECULAR PATHOGENESIS OF MODYS, 2000, 15 : 209 - 218
  • [29] Adiponectin enhances insulin signaling by increasing IRS-2 protein in liver
    Awazawa, Motoharu
    Ueki, Kohjiro
    Kaneko, Kazuma
    Kubota, Naoto
    Yamauchi, Toshimasa
    Kadowaki, Takashi
    DIABETES, 2007, 56 : A390 - A390
  • [30] Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
    Dominici, FP
    Hauck, S
    Argentino, DP
    Bartke, A
    Turyn, D
    JOURNAL OF ENDOCRINOLOGY, 2002, 173 (01) : 81 - 94