Study of mice susceptibility to influenza virus (A/AICHI/2/68) under aerosol challenge considering the aerosol deposition in respiratory tract

被引：0

作者：

Sergeyev, A.N. ^{[1
]}

P'yankova, O.G. ^{[1
]}

Bulychev, L.E. ^{[1
]}

Petrischenko, V.A. ^{[1
]}

P'yankov, O.V. ^{[1
]}

Zhukov, A.V. ^{[1
]}

Ryzhikov, A.B. ^{[1
]}

Shishkina, L.N. ^{[1
]}

Yevtin, N.K. ^{[1
]}

Safatov, A.S. ^{[1
]}

机构：

[1] Inst of Aerobiology SRC VB 'Vector', Novosibirsk, Russia

来源：

Journal of Aerosol Science | 1999年 / 30卷 / Suppl. 1期

关键词：

Animal cell culture - Atmospheric humidity - Deposition - Dispersions - Isotopes - Pulmonary diseases - Temperature - Titration - Viruses;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The efficacy of polydispersed aerosol deposition in immunosuppressed outbred mice and aerogenic challenge by influenza virus were studied in small dynamic chamber at temperature 20-22 degree of C and relative humidity 50-70%. Physical mark was radio-active isotope (46Sc). Titration on chicken embryos was used for determination of 50% aerogenic infectious and lethal doses of the virus. The resulting data were analyzed.

引用