Static versus dynamic teboroxime myocardial perfusion SPECT in canines

被引：0

作者：

Kadrmas, D.J. ^{[1
]}

Di Bella, E.V.R. ^{[1
]}

Khare, H.S. ^{[1
]}

Christian, P.E. ^{[1
]}

Gullberg, G.T. ^{[1
]}

机构：

[1] Medical Imaging Research Lab, Salt Lake City, United States

来源：

IEEE Transactions on Nuclear Science | 2000年 / 47卷 / 3 III期

关键词：

Data acquisition - Data reduction - Image reconstruction - Nuclear instrumentation - Organic compounds - Parameter estimation - Reaction kinetics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Tc-99m-teboroxime is a perfusion tracer with high myocardial extraction, fast washing and washout kinetics, and excellent imaging properties. The fast kinetics pose some problems for static imaging, but they also allow for back-to-back stress/rest studies to be performed very quickly. Furthermore, such fast kinetics are ideally suited for dynamic imaging. We have compared static versus dynamic myocardial perfusion SPECT with teboroxime in canines using microsphere-derived flow values as the gold standard. Dynamic data were successfully acquired at rest and under adenosine stress in seven dogs using a fast serial scanning protocol. The data were analyzed in two ways: summing timeframes to create a single, static dataset with consistent projections; and 4D reconstruction and kinetic parameter estimation for a two compartment model. In both cases imaging data (voxel intensity or washing rate parameter) were correlated with flow values measured by microspheres. The static summing procedure that produced the best correlation with flow consisted of summing the projection data acquired from 60 to 180 seconds post-injection. The washing rate parameter was found to provide better correlation with flow than static image intensity in six of seven animals. When the data were pooled over all studies, washing provided significantly better correlation with flow than static imaging (p<0.01). We conclude that dynamic imaging of teboroxime with compartmental modeling provides a better measure of flow than can be obtained from static imaging techniques.

引用

页码：1112 / 1117