A statistical evaluation of the Youden matched-pairs procedure

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U.S. Food and Drug Administration, Dept. of Health and Human Services, Division of Mathematics, 200 C St., SW, Washington, DC 20204, United States ^{[1
]}

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J AOAC Int | / 2卷 / 375-381期

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AOAC INTERNATIONAL currently permits investigators to use the Youden Matched-Pairs Procedure to obtain estimates of the method performance indicators repeatability and reproducibility (Sr and SR, respectively). This report explains the statistical model assumptions upon which the procedure is based, provides validity tests for several of these assumptions, explains conditions under which Youdens' precision error is not consistent with precision estimate Sr or SR as defined by AOAC INTERNATIONAL, and indicates when precision estimates based on the procedure should be interpreted with caution or should not be used.

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