Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47phox: Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47phox, thereby activating the oxidase

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Dept. of Molec. and Struct. Biology, Kyushu Univ. Grad. Sch. of Med. Sci., 3-1-1 Maidaski, Higashi-ku, Fukuoka 812-8582, Japan [1 ]
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J Biol Chem | / 47卷 / 33644-33653期
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  • [1] Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47 phox - Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47 phox, thereby activating the oxidase
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