To explore the main problems of the northwest region of Yunnan province, and to bring forward strategic planning countermeasures, the ecologic-environmental status of the northwest region of Yunnan province is analyzed and assessed by integrating qualitative analysis method and quantitative assessment method. The main environmental problems of this region are: (1) urban environmental quality is deteriorating and the trend is disconcerting; (2) ecologic-environmental crisis is getting more and more serious; (3) the efforts made on environmental protection is far from the requirement. The protection of ecologic-environment and bio-diversity and culture-diversity of the northwest region of Yunnan province may greatly affect the social and economical development and ecologic-environmental protection of its downstream. To solve these problems, mass work should be done, such as enhancing people's environmental consciousness, improving environmental management and increasing environmental protection investment.