Study on the inclusion complex of amoxicillin and β-cyclodextrin

被引：0

作者：

Lu, Ya-Peng ^{[1
]}

Ren, Yong ^{[1
]}

Wang, Ya-Na ^{[1
]}

Yang, Xing-Hao ^{[1
]}

Liu, Hua-Hong ^{[2
]}

Xu, Cai-Ping ^{[2
]}

机构：

[1] Jiangsu Research Center of Biomedical Functional Materials Engineering, Center of Drug Discovery, Nanjing Normal University, Nanjing 210097, China

[2] Nanjing Chengong Medicine Manufacturing Co., Ltd., Nanjing 210038, China

来源：

Chinese Pharmaceutical Journal | 2005年 / 40卷 / 10期

关键词：

Amoxicillin preparation - Dissolution rates - Inclusion complex - Trituration;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

OBJECTIVE: The inclusion complex of amoxicillin/β-cyclodextrin was investigated to improve the performance of the amoxicillin preparation. METHODS: In aqueous solution, the inclusion complex of amoxicillin/β-cyclodextrin was studied by Ultraviolet Spectroscopy and phase solubility. The inclusion complex was prepared by trituration and was confirmed by DTA and X-ray diffraction. The dissolution rates of amoxicillin and inclusion complex were compared. RESULTS: In aqueous solution, inclusion complex easily formed between amoxicillin and β-cyclodextrin. In the presence of 6.16 × 10 -3 mol &middot L-1 β-cyclodextrin, the solubility of inclusion complex was 3.89 times than that of amoxicillin. The dissolution rate in 10 minutes was 8.2 times as much as that of amoxicillin. CONCLUSION: The solubility and dissolution of amoxicillin were improved with β-cyclodextrin.

引用

页码：757 / 759

共 50 条

[1] Study of the podophyllotoxin/β-cyclodextrin inclusion complex
Ma, XY
Liao, ZX
Zhang, YL
Chen, YZ
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2000, 36 (03) : 335 - 342
[2] Study on inclusion complex of β-cyclodextrin and β-carotene
Zhongguo Yaoxue Zazhi/Chinese Pharmaceutical Journal, 1998, 33 (09): : 543 - 545
[3] Study of the Podophyllotoxin β-Cyclodextrin Inclusion Complex
Xue-Yi Ma
Zhi-Xin Liao
Yan-Ling Zhang
Yao-Zu Chen
Journal of inclusion phenomena and macrocyclic chemistry, 2000, 36 : 335 - 342
[4] Study of inclusion complex of β-cyclodextrin and nitrobenzene
Chen, M
Diao, GW
Zhang, ER
CHEMOSPHERE, 2006, 63 (03) : 522 - 529
[5] Theoretical Study on the Inclusion Complex of β-Cyclodextrin and Nitrobenzene
Xie Ju
Yin Ya-Xing
Jin Guo-Lian
He Mao-Xia
Diao Guo-Wang
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2011, 30 (05) : 706 - 716
[6] Theoretical Study on the Inclusion Complex of β-Cyclodextrin and Nitrobenzene
解菊
殷亚星
金国莲
何茂霞
刁国旺
结构化学, 2011, 30 (05) : 706 - 716
[7] Study on inclusion complex of decanoyl acetaldehyde-β-cyclodextrin
Wei, Shichao
Xu, Lijun
Zeng, Qin
Zhongguo Yaoxue Zazhi/Chinese Pharmaceutical Journal, 34 (03): : 167 - 169
[8] Theoretical and experimental study of the tetracain/β-cyclodextrin inclusion complex
N. L. Chekirou
I. Benomrane
F. Lebsir
A. M. Krallafa
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2012, 74 : 211 - 221
[9] Preformulation Study of the Inclusion Complex Irbesartan-β-Cyclodextrin
Hirlekar, Rajashree
Kadam, Vilasrao
AAPS PHARMSCITECH, 2009, 10 (01): : 276 - 281
[10] Preformulation study of the inclusion complex warfarin-β-cyclodextrin
Zingone, G
Rubessa, F
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2005, 291 (1-2) : 3 - 10

← 1 2 3 4 5 →