Preliminary results of a long-term program to investigate the tectonic history of the Gulf of Mexico principally through the use of multichannel seismic reflection methods indicate that knowledge of the deep part of the Gulf contributes significantly to understanding of the evolution of its continental margins. Reasonable and usual stratigraphic principles, based on marine reflection data, can be used successfully to interpret the geologic history of such regions. The large deep-sea cone of the present Mississippi River is a prominent and unique feature of the Gulf of Mexico.