Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis

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作者：
Wang, Shi-Long
Wang, Mei
Sun, Xiao-Yu
Zhang, Chao-Jie
Ma, Xiu-Wen
Ni, Ya-Ming
Yao, Si-De
Wang, Wen-Feng
机构：
[1] Analysis and Research Centre, Tongji University, Shanghai 200092, China
[2] Laboratory of Radiation Chemistry, Shanghai Inst. of Nuclear Research, Academia Sinica, Shanghai 201800, China
来源：
Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities | 2000年 / 21卷 / 01期
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摘要：
One-electron reduction potential is one of the important parameters of radiosensitive compound with a high electron affinity. In this work one-electron reduction potentials of podophyllotoxin and its derivatives were determined by pulse radiolysis using duroquinone as references. The one-electron reduction potentials of podophyllotoxin, 4 prime -demethylepipodophyllotoxin(DMEP) and etoposide (VP-16) are -310 mV, -339 mV, -334 mV, respectively.
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