Microbial isopenicillin N synthase genes: Structure, function, diversity and evolution

被引：0

作者：

Cohen, G. ^{[1
]}

Shiffman, D. ^{[1
]}

Mevarech, M. ^{[1
]}

Aharonowitz, Y. ^{[1
]}

机构：

[1] George S. Wise Faculty of Life Sciences, Department of Microbiology, Tel Aviv University, Ramat Aviv 69978, Israel

来源：

Trends in Biotechnology | 1990年 / 8卷 / 04期

关键词：

Bacteriology; -; Fungi;

D O I：

暂无

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学科分类号：

摘要：

Clinically and economically, penicillins and cephalosporins are the most important class of the β-lactam antibiotics. They are produced by a wide variety of microorganisms including numerous species of Streptomyces, some unicellular bacteria and several filamentous fungi. A key step common to their biosynthetic pathways is the conversion of a linear, cysteine-containing tripeptide to a bicyclic β-lactam antibiotic by isopenicillin N synthase. Recent successes in the cloning and expression of isopenicillin N synthase genes now permit production of a plentiful supply of this enzyme, which may be used for structural and mechanistic studies, or for biotechnological applications in the creation of novel β-lactam compounds from peptide analogues.

引用

页码：105 / 111