Synthesis and stereochemistry of trifluoromethyl-containing isoxazolidines

被引：0

作者：

Nenajdenko, V.G. ^{[2
]}

Sanin, A.V. ^{[1
]}

Tok, O.L. ^{[2
]}

Balenkova, E.S. ^{[2
]}

机构：

[1] M. V. Lomonosov Moscow State University, Moscow 119899, Russia

[2] A. N. Nesmeyanov Institute of Elementorganic Compounds, Russian Academy of Sciences, Moscow 117907, Russia

来源：

Chemistry of Heterocyclic Compounds | 1999年 / 35卷 / 03期

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摘要：

The reaction of trifluoromethyl-containing enones with hydroxylamine under various conditions is studied. The products in basic medium are equilibrating mixtures of isoxazolidine diastereomers in an ∼1:1 ratio. The energy of the nitrogen atom inversion barrier in these compounds is 50-60 kJ/mol. Broadened signals are observed at room temperature in the 1H and 13C NMR. ©1999 KluwerAcademic/Plenum Publishers.

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页码：348 / 357