Studies on the reaction between N-phosphoryl amino acids and ribonucleosides

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Hu, Jian-Jun
Ju, Yong
Zhao, Yu-Fen
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The interaction between N-phosphoryl amino acids and nucleosides in aqueous medium was studied and the products were analyzed on the basis of HPLC and LC-MS-MS techniques. The results demonstrated that peptides and oligonucleotides were simultaneously formed. Different selectivities were observed between the reaction of various kinds of N-phosphoryl amino acids and different nucleosides. The code results gave some clue for the chemical characteristics of the origin of primordial genetic code.
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页码:1667 / 1670
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