Functionalized calcium phosphate nanoparticles for biomedical application

被引：19

作者：

Epplea M. ^{[1
]}

Kovtunb A. ^{[1
]}

机构：

[1] Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, D-45117 Essen

来源：

Key Engineering Materials | 2010年 / 441卷

关键词：

Calcium phosphate; Drug delivery; Gene therapy; Nanoparticles; Transfection;

D O I：

10.4028/www.scientific.net/KEM.441.299

中图分类号：

学科分类号：

摘要：

Calcium phosphate is a natural biomineral and therefore possesses an excellent biocompatibility due to its chemical similarity to human hard tissue (bone and teeth). Calcium phosphate nanoparticles can be precipitated under controlled conditions and used as carrier in biological systems, e.g. to transfer nucleic acids or drugs. Such nanoparticles can also be suitably functionalized with fluorescing dyes, polymeric agents, pro-drugs or activators. The small monodisperse nanoparticles only mildly influence the intracellular calcium level and therefore are not toxic for cells. © (2010) Trans Tech Publications.

引用

页码：299 / 305

页数：6

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