A Three-Component Condensation of 2,5-Dialkyl-Phenols, Isobutyric Aldehyde, and Nitriles. Synthesis of New 2-Azaspiro[4.5]Deca-6,9-Dien-8-Ones and 2-Azaspiro[4.5]Deca-1,6,9-Trien-8-Ones

被引：3

作者：

Rozhkova, Yu. S. ^{[1
]}

Galata, K. A. ^{[1
]}

Vshivkova, T. S. ^{[1
]}

Shklyaev, Yu. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Ural Branch, Inst Tech Chem, Perm 614107, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 50卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

2-azaspiro[4.5]deca-6,9-dien-8-ones; 2-azaspiro[4.5]deca-1,6,9-trien-8-ones; 2,5-dimethyl-phenol; isobutyric aldehyde; 2-isopropyl-5-methylphenol; nitrile; sulfuric acid; multicomponent reactions; SPIROCYCLOHEXADIENONES;

D O I：

10.1007/s10593-014-1462-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The interaction of 2,5-dialkylphenols (2,5-dimethylphenol and 2-isopropyl-5-methylphenol) with isobutyric aldehyde and nitriles in the presence of concentrated sulfuric acid as catalyst resulted in the formation of 1-R-9-alkyl-3,3,6-trimethyl-2-azaspiro[4.5]deca-6,9-dien-8-ones and 1-R-9-alkyl-3,3,6-trimethyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones.

引用

页码：204 / 210

页数：7