Transition Metal Complexes as Therapeutics: A New Frontier in Combatting Neurodegenerative Disorders through Protein Aggregation Modulation

被引：4

作者：

Navale, Govinda R. ^{[1
]}

Ahmed, Imtiaz ^{[1
]}

Lim, Mi Hee ^{[2
]}

Ghosh, Kaushik ^{[1
,3
]}

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Korea Adv Inst Sci & Technol KAIST, Dept Chem, Daejeon 34141, South Korea

[3] Indian Inst Technol, Dept Biosci & Bioengn, Roorkee 247667, Uttar Pradesh, India

来源：

ADVANCED HEALTHCARE MATERIALS | 2024年 / 13卷 / 31期

基金：

新加坡国家研究基金会;

关键词：

Alzheimer's disease; metal complexes; neurodegenerative disorders; Parkinson's disease; prion disease; AMYLOID-BETA PEPTIDE; RUTHENIUM(II) POLYPYRIDYL COMPLEXES; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; C-TERMINAL REGION; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; IN-VITRO; ACETYLCHOLINESTERASE INHIBITORS; THIOSEMICARBAZONE COMPLEXES; BIOINORGANIC CHEMISTRY;

D O I：

10.1002/adhm.202401991

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Neurodegenerative disorders (NDDs) are a class of debilitating diseases that progressively impair the protein structure and result in neurological dysfunction in the nervous system. Among these disorders, Alzheimer's disease (AD), prion diseases such as Creutzfeldt-Jakob disease (CJD), and Parkinson's disease (PD) are caused by protein misfolding and aggregation at the cellular level. In recent years, transition metal complexes have gained significant attention for their potential applications in diagnosing, imaging, and curing these NDDs. These complexes have intriguing possibilities as therapeutics due to their diverse ligand systems and chemical properties and can interact with biological systems with minimal detrimental effects. This review focuses on the recent progress in transition metal therapeutics as a new era of hope in the battle against AD, CJD, and PD by modulating protein aggregation in vitro and in vivo. It may shed revolutionary insights into unlocking new opportunities for researchers to develop metal-based drugs to combat NDDs.

引用

页数：37