Design, Synthesis and biological activity evaluation of novel anticancer agent 5-(2-Carboxyethenyl)indole derivatives

被引：0

作者：

Han, Kailin ^{[1
,2
,3
]}

Wang, Haomeng ^{[1
,2
,3
]}

Song, Binbin ^{[1
,2
,3
]}

Li, Yashan ^{[1
,2
,3
]}

Ding, Wei Na ^{[1
,2
,3
]}

Zhao, Hongye ^{[1
,2
,3
]}

Sun, Hua ^{[1
,2
,3
]}

Teng, Yuou ^{[1
,2
,3
]}

Yu, Peng ^{[1
,2
,3
]}

机构：

[1] Key Lab of Industrial Fermentation Microbiology, Tianjin University of Science and Technology, Ministry of Education, Tianjin, China

[2] Tianjin Key Lab of Industrial Microbiology, Tianjin University of Science and Technology, Tianjin, China

[3] Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, Tianjin University of Science and Technology, Tianjin, China

来源：

Journal of Chemical and Pharmaceutical Research | 2014年 / 6卷 / 09期

关键词：

Polycyclic aromatic hydrocarbons - Cell culture - Chemical reactions;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of novel 5-(2-Carboxyethenyl) indole derivatives were designed and synthesized about 38-48% overall yields. Two of the seven newly synthesized compounds, compound 5 and 7, have not been reported before. Their structures were characterized on the basis of 1H, 13C NMR, and those compounds were tested for their anticancer activities against K562 and HT-29 cell lines. Results indicated that compounds 5, 6 and 7 containing 5-(2-Carboxyethenyl)indole derivatives demonstrated significant anticancer activity against HT-29 cell, their potency reached 4.67, 8.24 and 6.73 μM, respectively. © 2014, Journal of Chemical and Pharmaceutical Research. All rights reserved.

引用

页码：376 / 380