Preparation of chitosan antibacterial microparticles via ionic cross-linking intensified by Venturi-tube based hydrodynamic cavitation

被引：0
作者：
Zhang K.-M. [1 ]
Lu X.-J. [1 ]
Huang Y.-C. [1 ]
Huang C.-D. [1 ]
Yang F. [1 ]
Ren X.-E. [1 ]
Guo Y. [1 ]
机构：
[1] School of Biological and Chemical Engineering, Guangxi Key Laboratory of Green Processing of Sugar Resources, Guangxi University of Science and Technology, Liuzhou
来源：
Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities | 2019年 / 33卷 / 01期
关键词：
Chitosan; Hydrodynamic cavitation; Microparticle; Particle size distribution; Venturi tube;
D O I：
10.3969/j.issn.1003-9015.2019.01.029
中图分类号：
学科分类号：
摘要：
Chitosan microparticles loaded with a model antimicrobial agent methylisothiazolinone (MIT) was prepared via ionic cross-linking which was intensified by Venturi tube-based cavitation. Effects of ingredients and process conditions on mean particle size and encapsulation efficiency were studied and the performance was compared with that of mechanical agitation. The results show that the mass ratio of sodium tripolyphosphate (TPP) and chitosan is a critical factor in determining mean particle size, and microparticles can be stably obtained by cavitation with mass ratio of 2:15~6:15. The optimal preparation conditions are: cavitation inlet pressure = 0.2 MPa, cavitation time = 20 min, chitosan mass concentration = 3.0 g∙L-1, mass ratio of TPP and chitosan = 6:15 and MIT concentration = 0.5 mmol∙L-1. The obtained microparticles show good dispersion, round shape and narrow size distribution with mean particle size = 329.4 nm. The encapsulation efficiency is (62.3±2.57)%. Compared with the microparticles prepared by mechanical agitation, the mean particle size is decreased by at least 20.5% and the encapsulation efficiency is increased by at least 17.7%. The Venturi tube-based cavitation is suitable for intensification in the preparation of chitosan antibacterial microparticles. © 2019, Editorial Board of Journal of Chemical Engineering of Chinese Universities". All right reserved."
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页码：219 / 227
页数：8
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