Electrospinning of Poly-3-Hydroxybutyrate Fibers Loaded with Chlorophyll for Antibacterial Purposes

被引：0

作者：

Tyubaeva, Polina M. ^{[1
,2
]}

Varyan, Ivetta A. ^{[1
,2
]}

Romanov, Roman R. ^{[2
]}

Merzlikin, Vasily A. ^{[1
]}

Gruznova, Olga A. ^{[3
,4
]}

Gruznov, Dmitry V. ^{[5
]}

Popov, Nikolay I. ^{[4
]}

Shcherbakova, Gulizar Sh. ^{[4
]}

Shuteeva, Ekaterina N. ^{[4
]}

Chesnokova, Irina P. ^{[3
,6
]}

Lobanov, Anton V. ^{[7
]}

Olkhov, Anatoly A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Dept Phys Chem Synthet & Nat Polymer Composit, 4 Kosygina St, Moscow 119334, Russia

[2] Plekhanov Russian Univ Econ, Acad Dept Innovat Mat & Technol Chem, 36 Stremyanny Per, Moscow 117997, Russia

[3] Russian Acad Sci, Semenov Fed Res Ctr Chem Phys, Lab Liquid Phase Oxidat, 4 Kosygina St, Moscow 119334, Russia

[4] Russian Acad Sci, Ya R Kovalenko All Russian Res Inst Expt Vet Med, All Russian Res Inst Vet Sanitat Hyg & Ecol, Branch Fed State Budget Sci Inst Fed Sci Ctr KI Sk, 5 Zvenigorodskoye Highway, Moscow 123022, Russia

[5] Russian Acad Sci, Branch Fed State Budget Sci Inst Fed Sci Ctr KI Sk, All Russian Res Inst Vet Sanitat Hyg & Ecol, Ya R Kovalenko All Russian Res Inst Expt Vet Med,L, 5 Zvenigorodskoye Highway, Moscow 123022, Russia

[6] Russian Technol Univ, Dept Chem & Technol High Mol Cpds, MIREA, 78 Vernadsky Ave, Moscow 119454, Russia

[7] Moscow Pedag State Univ, Dept Gen Chem, 1-1 Malaya Pirogovskaya St, Moscow 119435, Russia

来源：

POLYMERS | 2024年 / 16卷 / 22期

关键词：

poly-3-hydroxybutyrate; electrospinning; chlorophyll; antibacterial properties; POLYHYDROXYBUTYRATE; CRYSTALLIZATION; NANOPARTICLES; DEGRADATION; NANOFIBERS; PREVENTION; TOXICITY; GLYCEROL; BEHAVIOR; RELEASE;

D O I：

10.3390/polym16223221

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This work is devoted to the creation of biocompatible fibrous materials with a high antimicrobial effect based on poly-3-hydroxybutyrate (PHB) and chlorophyll (Chl). The data obtained show the possibility of obtaining fibrous materials from PHB and Chl by electrospinning methods. The obtained electrospun matrices were investigated by the SEM, DSC and FTIR methods. Various key properties of the matrices were evaluated, including hydrophilicity and mechanical strength, as well as photodynamic and light-dependent antimicrobial effects against the conditionally pathogenic microorganism Staphylococcus aureus. The results demonstrate a significant improvement in electrospinning properties for a concentration of 0.5% Chl and a reduction in fiber formation defects, as well as an increase in the strength of nonwovens. It was found that the antimicrobial potential of Chl-PHB (with concentrations of Chl of 1.25 and 1.5%) is higher than that of Chl in free form. It was also determined that irradiation increases the inhibitory effect of Chl, both in free form and in the form of a complex with a polymer.

引用

页数：21

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